学　术

　　教师发展中心“学者论坛”活动特别邀请阿根廷布宜诺斯艾利斯国立大学 Siliva Kochen 教授作学术交流，具体安排如下，欢迎广大师生参加。

　　一、主　题：Epilepsy and Cognition Translational research from molecular levels to the patient

　　二、主讲人：阿根廷布宜诺斯艾利斯国立大学 Siliva Kochen 教授

　　三、时 间：2023年9月11日（周一）15:00-16:00

　　四、地　点：清水河校区综合楼131会议室

　　五、内容简介：

　　Our team focuses on translational research for patients with refractory epilepsy. Epilepsy surgery is crucial, relying on accurate preoperative localization of the epileptogenic zone (EZ). We use Stereoelectroencephalography (SEEG) to anatomically define the EZ and functional cortical areas for personalized surgical interventions. SEEG allows us to study memory, language, and motor activity in conscious subjects. We identify physiological markers that distinguish EZ neurons from those associated with early-stage epileptic network activation. Additionally, microelectrodes record individual neuron activity in the hippocampus and amygdala. By presenting stimuli like famous individuals or objects, we've discovered "concept cells" (CCs) that selectively respond to specific memories, supporting the concept of "sparse coding." We explore CC formation, persistence, and their contrast with novel information.Neuroimaging projects involve brain MRI techniques, including high-resolution structural quantification, diffusion imaging, fiber tractography, and functional connectivity analysis using fMRI. Longitudinal and cross-sectional studies employ AI for automated classification and regression analysis of MRI images in epilepsy and neurodegenerative diseases.We also investigate cannabis, particularly cannabidiol, as an adjunctive therapy for refractory epilepsy. This treatment is effective, safe, well-tolerated, and improves patients' quality of life.Another research focus is healthy aging and memory impairments, including Alzheimer's disease. We employ Cognitive Stimulation Therapy (CST) as a non-pharmacological intervention, benefiting cognition and quality of life in dementia patients. Additionally, we study genetic factors associated with Alzheimer's disease and related dementias to gain new insights.

　　六、主讲人简介：

　　Silvia Kochen，阿根廷布宜诺斯艾利斯国立大学神经学教授，阿根廷国际癫痫联盟委员会成员，哥伦比亚大学医学部神经内科教授，总发表论文118篇，H-index：20。Silvia Kochen博士在癫痫和认知研究方面作出了重要贡献。她领导并指导了多个研究项目，探索了癫痫与认知功能之间的关系，为理解这一神经疾病的复杂性提供了重要见解。她的研究成果在国际期刊上广泛发表，并受到同行的高度认可。除了在学术界的卓越表现，Silvia Kochen博士还积极参与机构管理和科学组织。她担任多个委员会和董事会的成员，为科学技术的发展和推动提供了重要指导。此外，她是国际癫痫联盟（ILAE）和拉丁美洲癫痫学院（ALADE）等组织的成员，积极促进国际学术交流和合作。

　　七、主办单位：教师发展中心

　　　　承办单位：生命科学与技术学院